发明名称 |
Method of engineering chemotherapy drug resistant T-cells for immunotherapy |
摘要 |
The present invention relates to the use of "off-the-shelf" allogeneic therapeutic cells for immunotherapy in conjunction with chemotherapy to treat patients with cancer. In particular, the inventors develop a method of engineering allogeneic T-cell resistant to chemotherapeutic agents. The therapeutic benefits afforded by this strategy should be enhanced by the synergistic effects between chemotherapy and immunotherapy. In particular, the present invention relates to a method for modifying T-cells by inactivating at least one gene encoding T-cell receptor component and by modifying said T-cells to confer drug resistance. The invention opens the way to standard and affordable adoptive immunotherapy strategies for treating cancer. |
申请公布号 |
AU2014351797(A1) |
申请公布日期 |
2016.06.09 |
申请号 |
AU20140351797 |
申请日期 |
2014.11.21 |
申请人 |
CELLECTIS |
发明人 |
VALTON, JULIEN;DUCHATEAU, PHILIPPE;SOURDIVE, DAVID |
分类号 |
C12N5/0783 |
主分类号 |
C12N5/0783 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|