| 摘要 |
The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in medicine, more particularly in the treatment/diagnosis of acute and chronic inflammatory diseases, viral infections, cancer, degenerative muscle diseases, neurodegenerative diseases and damage that is associated with calcium homeostasis impairment. The novel cyclosporin derivatives additionally have no immunosuppressive effect. |
| 申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.;LEAD DISCOVERY CENTER GMBH |
发明人 |
FISCHER, GUNTER;MALESEVIC, MIROSLAV;ERDMANN, FRANK;KUHLING, JAN;BUKRINSKY, MICHAEL;CONSTANT, STEPHANIE;RUHTER, GERD;NUSSBAUMER, PETER;DINKEL, KLAUS |
