发明名称 |
MODIFIED FIBROBLAST GROWTH FACTOR 1 (FGF-1) POLYPEPTIDES WITH INCREASED BINDING AFFINITY FOR HEPARIN AND ASSOCIATED METHODS |
摘要 |
A modified FGF-1 polypeptide that has an increased binding affinity for heparin relative the wild-type human FGF-1's binding affinity for heparin is described. The modified FGF-1 polypeptide has at least 80% amino acid sequence identity to wild-type human FGF-1 having SEQ ID NO: 1. The serine at an amino acid position of the modified FGF-1 polypeptide corresponding to amino acid position 116 of SEQ ID NO: 1 is substituted by an amino acid that increases the modified FGF-1 polypeptide's binding affinity for heparin relative to the binding affinity of SEQ ID NO: 1 to heparin. |
申请公布号 |
WO2016089945(A1) |
申请公布日期 |
2016.06.09 |
申请号 |
WO2015US63333 |
申请日期 |
2015.12.02 |
申请人 |
FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. |
发明人 |
BLABER, MICHAEL;XIA, XUE |
分类号 |
C07K14/50;C12N15/85 |
主分类号 |
C07K14/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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