发明名称 |
RAAV VECTOR COMPOSITIONS HAVING TYROSINE-MODIFIED CAPSID PROTEINS AND METHODS FOR USE |
摘要 |
Disclosed are tyrosine-modified rAAV vectors, as well as infectious virions, compositions, and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and methods for using the disclosed tyrosine-phosphorylated capsid protein mutant rAAV vectors in a variety of diagnostic and therapeutic applications including in vivo and ex vivo gene therapy, and large-scale production of rAAV vectors. |
申请公布号 |
EP2191001(B1) |
申请公布日期 |
2016.06.08 |
申请号 |
EP20080733161 |
申请日期 |
2008.04.08 |
申请人 |
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. |
发明人 |
ZHONG, LI;ZOLOTUKHIN, SERGEI;GOVINDASAMY, LAKSHMANAN;AGBANDJE-MCKENNA, MAVIS;SRIVASTAVA, ARUN |
分类号 |
C12N15/864;A61K38/16;A61K48/00 |
主分类号 |
C12N15/864 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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