发明名称 |
NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF |
摘要 |
The present invention relates to novel compounds of Formula I
and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines using N-sp3 protective groups. The invention also provides intermediates for use in the synthesis of compounds of Formula I. |
申请公布号 |
EP3029042(A1) |
申请公布日期 |
2016.06.08 |
申请号 |
EP20150201386 |
申请日期 |
2012.10.03 |
申请人 |
EUROSCREEN S.A. |
发明人 |
HOVEYDA, HAMID;DUTHEUIL, GUILLAUME;FRASER, GRAEME;ROY, MARIE-ODILE;EL BOUSMAQUI, MOHAMED;BATT, FRÉDÉRIC |
分类号 |
C07D487/04;A61K31/4985;A61P25/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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