发明名称 |
A PROCESS FOR PREPARING RIFAXIMIN K |
摘要 |
The present invention relates to a process for obtaining rifaximin &kgr; comprising the following steps: a) reacting rifamycin O with 2-amino-4-picoline in the presence of a solvent mixture comprising water and a solvent selected from methyl isobutylketone, ethylacetate and a water soluble solvent; b) obtaining a rifaximin solution by removing the aqueous phase; c) obtaining rifaximin &kgr; from the rifaximin solution, wherein when the solvent is a water soluble solvent, either methyl isobutylketone or ethylacetate is further added in step a). In another aspect the process of the invention relates to a process for obtaining the crystalline form &kgr; of rifaximin comprising the following steps: i) contacting rifaximin or a rifaximin solution with exclusively ethylacetate, ii) obtaining the rifaximin in crystalline form &kgr; by removing ethylacetate. |
申请公布号 |
EP3027626(A1) |
申请公布日期 |
2016.06.08 |
申请号 |
EP20140757857 |
申请日期 |
2014.08.01 |
申请人 |
CLAROCHEM IRELAND LIMITED |
发明人 |
VIGANO', ENRICO;MOLTENI, RENATO;LANFRANCONI, SIMONA;ARRIGHI, MASSIMILIANO;GATTI, FABIO |
分类号 |
C07D498/22 |
主分类号 |
C07D498/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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