| 摘要 |
PROBLEM TO BE SOLVED: To predict toxicity about a compound where its toxicity is unknown.SOLUTION: A method includes analyzing the metabolic pattern of a compound using two or more cytochrome P450's selected from the group consisting of CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2A13, CYP2B6, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2D6, CYP2E1, CYP2J2, CYP2R1, CYP2W1, CYP3A4, CYP3A5, CYP4F2, CYP4F12, CYP4X1, CYP17A1, CYP27A1 and CYP51A1, and predicting the toxicity of the compound, based on the results of the analysis. |
