| 发明名称 |
抗ＧＰＲ−９−６および抗ＴＥＣＫ抗体ならびにＧＰＲ−９−６およびＴＥＣＫの機能の調節因子の同定方法 |
| 摘要 |
The invention relates to an antibody or antigen-binding fragment thereof which binds to the CC chemokine receptor GPR-9-6 and blocks the binding of a ligand (e.g., TECK) to the receptor. The invention also relates to a method of identifying agents (molecules, compounds) which can bind to GPR-9-6 and inhibit the binding of a ligand (e.g., TECK) and/or modulate a function of GPR-9-6. The invention further relates to a method of modulating a function of GPR-9-6, and to the use of the antibodies, antigen-binding fragments and agents identified by the method of the invention in research, therapeutic, prophylactic and diagnostic methods. |
| 申请公布号 |
JP5933204(B2) |
申请公布日期 |
2016.06.08 |
| 申请号 |
JP20110178577 |
申请日期 |
2011.08.17 |
| 申请人 |
ミレニアム ファーマシューティカルズ， インコーポレイテッドＭＩＬＬＥＮＮＩＵＭ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬＳ， ＩＮＣ． |
发明人 |
アンドリュー，デビッド，ピー．;ザベル，ブライアン，エイ．;ポナース，ポール，ディー． |
| 分类号 |
C07K16/28;G01N33/50;A61K39/395;A61K45/00;A61P1/00;A61P1/16;A61P1/18;A61P3/10;A61P5/14;A61P9/00;A61P9/10;A61P11/00;A61P11/06;A61P13/12;A61P15/08;A61P17/00;A61P17/06;A61P19/02;A61P21/00;A61P21/04;A61P25/00;A61P29/00;A61P35/00;A61P35/02;A61P35/04;A61P37/00;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07K16/24;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/02;C12N15/09;C12P21/08;C12Q1/02;G01N33/15;G01N33/53;G01N33/536;G01N33/566;G01N33/577;G01N33/58 |
主分类号 |
C07K16/28 |
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