发明名称 FORMATION OF CHIRAL 4-CHROMANONES USING CHIRAL PYRROLIDINES
摘要 The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific.
申请公布号 US2016152588(A1) 申请公布日期 2016.06.02
申请号 US201414902873 申请日期 2014.07.03
申请人 DAM IP ASSETS B.V. 发明人 ACKERMANN Stephan;LETINOIS Ulla
分类号 C07D311/22 主分类号 C07D311/22
代理机构 代理人
主权项 1. Process for the manufacturing of a compound of formula (I) comprising the step of reacting a composition consisting of compound of formula (II-A);compound of formula (II-B) or a ketal thereof andat least one chiral compound of formula (II-C) wherein R1, R3 and R4 are independently from each other hydrogen or methyl groups; R2 and R2′ represents hydrogen or a phenol protection group; R5 represents either a linear or branched completely saturated C6-25-alkyl group or a linear or branched C6-25-alkyl group comprising at least one carbon-carbon double bond; Y1 represents either CH2Y2 or wherein R6 represents a linear or branched C1-12-alkyl group which optionally further comprises at least one aromatic group and/or C═O and/or NH and/or NH2 group; Y2 represents either OH or OR7 or NHR7 or NHCOOR7 or wherein R7 represents either a linear or branched C1-12-alkyl group which optionally further comprises at least one aromatic group and/or C═O and/or NH and/or NH2 group or an aryl group or a substituted aryl group or a heteroaryl group or a substituted heteroaryl group; and the dotted line(s) represents the bond(s) by which the corresponding substituent is bound to the rest of formula (II-C); and wherein * represents the chiral centre of the chiral isomer of formula (I).
地址 Heerlen NL