发明名称 Compositions and Methods for Treating Neuropsychiatric Disorders Using an Endothelin-B Receptor Agonist
摘要 The present invention relates to compositions and methods for treating neuropsychiatric disorders in vertebrates and humans. More specifically, the present invention provides for use of IRL-1620, an endothelin-B receptor agonist, in appropriate doses to be a neuroprotective and a neuroregenerative agent. Accordingly, in one aspect the disclosure provides a method of treating a neuropsychiatric disorder comprising administering to a patient in need thereof a therapeutically effective amount of an endothelin-B receptor agonist to treat the neuropsychiatric disorder. In some embodiments, the endothelin-B receptor agonist is co-administered with an additional agent to treat the neuropsychiatric disorder. In some embodiments, the additional agent is selected from the group consisting of an antidepressant, an anti-inflammatory agent, a CNS stimulant, a neuroleptic, and an anti-proliferative agent.
申请公布号 US2016151450(A1) 申请公布日期 2016.06.02
申请号 US201414903574 申请日期 2014.07.08
申请人 MIDWESTERN UNIVERSITY 发明人 Gulati Anil
分类号 A61K38/10;A61K45/06 主分类号 A61K38/10
代理机构 代理人
主权项 1. A method of treating a neuropsychiatric disorder comprising administering to a patient in need thereof a therapeutically effective amount of an endothelin-B receptor agonist to treat the neuropsychiatric disorder.
地址 Downers Grove IL US