| 主权项 |
1. A method for inhibiting poly (ADP-ribose) polymerase (PARP) in a subject in need thereof, comprising administering to the subject a pharmaceutical composition comprising one or more pharmaceutically acceptable carriers or excipients, and a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein A and B are taken together with the attached carbon atoms to form an aryl or heteroaryl, wherein the aryl or heteroaryl is each independently and optionally substituted with one or more groups selected from the group consisting of an alkyl, halogen, hydroxyl, alkoxyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —C(O)OR5, —OC(O)R5, —O(CH2)nC(O)OR5, —C(O)R5, —NHC(O)R5, —NR6R7, —OC(O)NR6R7 and —C(O)NR6R7; R1, R2, R3 and R4 are each independently selected from the group consisting of hydrogen, a halogen, alkyl, cyano and alkoxyl, wherein the alkyl or alkoxyl is each independently and optionally substituted with one or more groups selected from the group consisting of a halogen, hydroxyl, alkyl and alkoxyl; D, E, and G are each independently selected from the group consisting of a nitrogen atom and C(R8); R5 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is each independently and optionally substituted with one or more groups selected from the group consisting of an alkyl, halogen, hydroxyl, alkoxyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, carboxyl and alkoxycarbonyl; R6 and R7 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is each independently and optionally substituted with one or more groups selected from the group consisting of an alkyl, halogen, hydroxyl, alkoxyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, carboxyl and alkoxycarbonyl; alternatively, R6 and R7 are taken together with the attached N atom to form a heterocyclyl, wherein the heterocyclyl contains one or more N, O or S(O)m heteratoms, and the heterocyclyl is optionally substituted with one or more groups selected from the group consisting of an alkyl, halogen, hydroxyl, alkoxyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, carboxyl and alkoxycarbonyl; R8 is selected from the group consisting of hydrogen, alkyl, halogen, hydroxyl, cyano, alkoxyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, benzyl, —C(O)OR5, —OC(O)R5, —O(CH2)nC(O)OR5, —(CH2)nNR6R7, —C(O)R5, —NHC(O)R5, —NR6R7, —OC(O)NR6R7 and —C(O)NR6R7, wherein the alkyl, alkoxyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or benzyl is each independently and optionally substituted with one or more groups selected from the group consisting of an alkyl, halogen, hydroxyl, alkoxyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, oxo, —C(O)OR5, —OC(O)R5, —O(CH2)nC(O)OR5, —C(O)R5, —NHC(O)R5, —NR6R7, —OC(O)NR6R7 and —C(O)NR6R7; m is selected from the group consisting of 0, 1 and 2; and n is selected from the group consisting of 0, 1 and 2. |
