| 发明名称 |
Method of Treating Dyskinesia |
| 摘要 |
Methods of treating patients with dyskinesias, by administering a therapeutically effective amount of a dual-action μ-opioid receptor antagonist/κ-opioid receptor agonists or prodrug thereof to a subject in need thereof, sufficient to mitigate the dyskinesia. Alternatively, a combination of both a mu-opioid receptor antagonist or prodrug thereof, and a kappa-opioid receptor agonist or prodrug thereof can be administered, either together or separately. |
| 申请公布号 |
US2016151359(A1) |
申请公布日期 |
2016.06.02 |
| 申请号 |
US201615019218 |
申请日期 |
2016.02.09 |
| 申请人 |
Rutgers, The State University of New Jersey |
发明人 |
Mouradian M. Maral;Braithwaite Steven;Voronkov Michael |
| 分类号 |
A61K31/485 |
主分类号 |
A61K31/485 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating or mitigating a dyskinesia, comprising administering to a subject in need thereof a therapeutically effective amount of a dual-action μ-opioid receptor antagonist/κ-opioid receptor agonist, wherein the dual-action μ-opioid receptor antagonist/κ-opioid receptor agonist comprises Nalbuphine or a Nalbuphine prodrug. |
| 地址 |
New Brunswick NJ US |
