TOPICAL COMPOSITION AND DELIVERY SYSTEM AND ITS USE

摘要

The described invention provides a topical delivery system comprising a pharmaceutical composition for application directly to a skin of a subject in need thereof comprising (a) an effective therapeutic amount of an active therapeutic agent; (b) chemical drivers comprising an amino benzoate local anesthetic, ethoxydiglycol and methylsulfonylmethane (MSM) that in combination are effective to synergistically deliver the therapeutic agent; and (c) a depot component for keeping the pharmaceutical composition in the skin. Methods for delivering an active therapeutic agent into skin, for keeping it in the skin, for reducing systemic side effects attributable to entry of the active agent into the blood stream, and a method for treating a condition, disease or disorder of skin topically also are described in accordance with the embodiments of the described invention.

主权项

1. A topical delivery system comprising a pharmaceutical composition formulated for application directly to a skin of a subject in need thereof comprising:
(a) a therapeutic amount of an active therapeutic agent to treat symptoms of a disease, disorder or condition; (b) chemical drivers comprising an amino benzoate local anesthetic, ethoxydiglycol and methylsulfonylmethane (MSM), wherein the chemical drivers are effective at acting synergistically to deliver the therapeutic agent; and (c) a depot component that is effective to keep the active agent locally in the skin and to reduce distribution of the active agent to the blood stream.