发明名称 |
Targeted Modified IL-1 Family Members |
摘要 |
The present disclosure relates to a modified Interleukin-1 (IL-1) family member cytokine, with reduced activity via its cytokine receptor, wherein said interleukin-1 family member cytokine is specifically delivered to target cells. Preferably, the IL-1 family member cytokine is a mutant, more preferably it is a mutant IL-1 with low affinity to the IL-1 receptor, wherein said mutant IL-1 is specifically delivered to target cells. The targeting is preferably realized by fusion of the modified IL-1 family member cytokine to a targeting moiety, preferably an antibody or antibody-like molecule. The disclosure relates further to the use of such targeted modified IL-1 family member cytokine to treat diseases. |
申请公布号 |
US2016152730(A1) |
申请公布日期 |
2016.06.02 |
申请号 |
US201414905352 |
申请日期 |
2014.07.04 |
申请人 |
VIB VZW ;UNIVERSITEIT GENT ;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ;UNIVERSTITÉ MONTPELLIER 2 ;CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE MONTPELLIER |
发明人 |
Tavernier Jan;Gerlo Sarah;Peelman Frank;Uze Gilles |
分类号 |
C07K16/40;C07K14/545 |
主分类号 |
C07K16/40 |
代理机构 |
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代理人 |
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主权项 |
1. A targeting construct, comprising a modified IL-1 family cytokine characterized by a reduced affinity for its receptor, and a targeting moiety. |
地址 |
Gent BE |