SUBSTITUTED PYRIDYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR.

摘要

Pyridylamide compounds of Formula: (I); wherein R1 is -C1-4alkyl or saturated monocyclic cycloalkyl; m is 1 or 2; X is N or CH; Y is N or CR3; Ra is -H, -Z-Ar, -CH2NRbRc, -CN, -CO2C1-4alkyl, -CO2H, or -CONRbRc; where Rb and Rc are each independently -H or -C1-4alkyl; and R2 is -H or -Z-Ar; with the proviso that one of X and Y is N and one of Ra and R2 is -Z-Ar; where Z is O or S; and Ar is a phenyl or monocyclic heteroaryl group unsubstituted or substituted with one, two, or three R3 substituents; where each R3 substituent is independently selected from the group consisting of: halo, -C1-4alkyl, -OH1 -OC1-4alkyl, -SC1-4alkyl, -CN, -CONRdRe, and -NO2; where Rd and Re are each independently -H or -C1-4alkyl; are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated1 diseases.