发明名称 Carboline Compounds Usable in The Treatment of Neurodegenerative Diseases
摘要 The present invention relates to a compound according to Formula (A) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, and its use.;
申请公布号 US2016152610(A1) 申请公布日期 2016.06.02
申请号 US201414900248 申请日期 2014.06.27
申请人 ALZPROTECT ;UNIVERSITE DE LILLE 2 DROIT ET SANTE ;INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE 发明人 MELNYK Patricia;CARATO Pascal;BURLET Stephane;NGUYEN Emilie;VERWAERDE Philippe;SERGEANT Nicolas;ESTRELLA Cecilia
分类号 C07D471/04 主分类号 C07D471/04
代理机构 代理人
主权项 1. A compound according to Formula (A) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, wherein X and Y are different from one another and are selected from: wherein n is an integer equal to 2 or superior to 2;m is an integer equal to 2 or superior to 2; andR2 and R3 are selected independently from one another from the groups consisting of: linear or branched (C1-C12) alkyl; linear or branched (C2-C12) alkenyl; linear or branched (C2-C12) alkynyl; said alkyl group, alkenyl group or alkynyl group may be substituted with at least one substituent selected from halogen, cycloalkyl, hydroxyl, alkoxy, amino, acylamino, aroylamino, heteroaroylamino and carboxy groups;heteroaroylamino;(C2-C6) heterocycloalkyl comprising in the cycle an oxygen atom and/or a nitrogen atom;benzyl optionally substituted with an alkyl group, halogen, an ether group and/or an amino group; orR2 and R3 form together with the nitrogen atom carrying them a saturated or unsaturated (C2-C7) heterocycle; R4 is selected from F, Cl, H, O—CH3, and —CH3; R5 is selected from H, CH3 and a phenyl group; with the proviso that R5 is H if X is not CH2.
地址 Loos FR