| 主权项 |
1. A compound of structural formula I: or a pharmaceutically acceptable salt thereof, wherein: X is —C(H)— or —N—; each R1 is independently selected from halo; haloalkyl; —(CH2)1-4R∘; —(CH2)0-4OR∘; —O—(CH2)0-4C(O)OR∘; —(CH2)0-4CH(OR∘)2; —(CH2)0-4SR∘; —(CH2)0-4-carbocyclyl, which may be substituted with R∘; —(CH2)0-4-aryl, which may be substituted with R∘; —(CH2)0-4-heterocyclyl, which may be substituted with R∘; —(CH2)0-4-heteroaryl, which may be substituted with R∘; —CH═CH-carbocyclyl, which may be substituted with R∘; —CH═CH-aryl, which may be substituted with R∘; —CH═CH-heterocyclyl, which may be substituted with R∘; —CH═CH-heteroaryl, which may be substituted with R∘; —NO2; —CN; —N3; —(CH2)0-4N(R∘)2; —(CH2)0-4N(R∘)C(O)R∘; —(CH2)0-4N(R∘)C(S)R∘; —(CH2)0-4N(R∘)C(O)NR∘2; —(CH2)0-4N(R∘)C(S)NR∘2; —(CH2)0-4N(R∘)C(O)OR∘; —(CH2)0-4N(R∘)N(R∘)C(O)R∘; —(CH2)0-4N(R∘)N(R∘)C(O)NR∘2; —(CH2)0-4N(R∘)N(R∘)C(O)OR∘; —(CH2)0-4C(O)R∘; —(CH2)0-4C(S)R∘; —(CH2)0-4C(O)OR∘; —(CH2)0-4C(O)SR∘; —(CH2)0-4OC(O)R∘; —(CH2)0-4OC(O)(CH2)0-4SR∘, —(CH2)0-4SC(S)SR∘; —(CH2)0-4SC(O)R∘; —(CH2)0-4C(O)NR∘2; —(CH2)0-4C(S)NR∘2; —(CH2)0-4C(S)SR∘; —(CH2)0-4OC(O)NR∘2; —(CH2)0-4C(O)N(OR∘)R∘; —(CH2)0-4C(O)C(O)R∘; —(CH2)0-4C(O)CH2C(O)R∘; —(CH2)0-4C(NOR∘)R∘; —(CH2)0-4SSR∘; —(CH2)0-4S(O)2R∘; —(CH2)0-4S(O)2OR∘; —(CH2)0-4OS(O)2R∘; —(CH2)0-4S(O)2NR∘2; —(CH2)0-4S(O)R∘; —(CH2)0-4N(R∘)S(O)2NR∘2; —(CH2)0-4N(R∘)S(O)2R∘; —(CH2)0-4N(OR∘)R∘; —(CH2)0-4C(NH)NR∘2; —(CH2)0-4P(O)2R∘; —(CH2)0-4P(O)R∘2; —(CH2)0-4OP(O)R∘2; —(CH2)0-4OP(O)(OR∘)2; —(CH2)0-4ON(R∘)2; and —(CH2)0-4C(O)O—N(R∘)2, wherein:
each R∘ is independently hydrogen, C1-6 aliphatic, —CH2-carbocyclyl, —CH2-aryl, —CH2-heterocyclyl, —CH2-hetero aryl, —O(CH2)0-1-carbocyclyl, —O(CH2)0-1-aryl, —O(CH2)0-1-heterocyclyl, —O(CH2)0-1-heteroaryl, carbocyclyl, aryl, heterocyclyl or heteroaryl, or two independent occurrences of R∘, taken together with their intervening atom(s), form a 3-12-membered carbocyclyl, aryl, heterocyclyl or heteroaryl; andeach R∘ and each ring formed from two independent occurrences of R∘, taken together with their intervening atom(s), are optionally and independently substituted with one or more substituents selected from the group consisting of halo, CN, OH, unsubstituted C1-C3 alkyl, halo-C1-C3 alkyl, —NH2, —NO2, —NH(unsubstituted C1-C3 alkyl), —N(unsubstituted C1-C3 alkyl)2, —O—C1-C3 alkyl, —C(O)OH, —C(O)O-(unsubstituted C1-C3 alkyl), —C(O)-(unsubstituted C1-C3 alkyl), —O-(unsubstituted C1-C3 alkyl), and —S-(unsubstituted C1-C3 alkyl); R2 is selected from optionally substituted heteroaryl and optionally substituted aryl; one of Ra and Rb is hydrogen, and the other is selected from —C(O)—N(R5)(R6), —CN, —C(O)—O—R3, —C(S)—O—R3, —C(S)—N(R5)(R6), —C(O)—N(R7)—N(R5)(R6), —C(S)—N(R7)—N(R5)(R6), —C(O)—N(R7)—N(R7)—C(O)—R4, —C(S)—N(R7)—N(R7)—C(O)—R4, —C(O)—N(R7)—N(R7)—C(S)—R4, —C(S)—N(R7)—N(R7)—C(S)—R4, —C(O)—N(R7)—N(R7)—S(O)1-2—R4 and —C(S)—N(R7)—N(R7)—S(O)1-2—R4, wherein:
R3 is selected from hydrogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, carbocyclyl, aryl, heterocyclyl and heteroaryl;R4 is selected from —N(H)(C3-C6 cycloalkyl), —N(C1-C4 alkyl)(C3-C6 cycloalkyl), —C1-C6 alkyl, —(C0-C4 alkylene)-carbocyclyl, —(C0-C4 alkylene)-heterocyclyl, —(C0-C4 alkylene)-aryl, and —(C0-C4 alkylene)-heteroaryl;R5 and R6 are each independently selected from hydrogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, carbocyclyl, aryl, heterocyclyl and heteroaryl; orR5 and R6 are taken together with the nitrogen atom to which they are commonly attached to form a heterocyclyl or heteroaryl;each R7 is independently hydrogen or C1-C4 alkyl; and n is 0, 1, 2, 3, 4 or 5; wherein:
unless otherwise designated, each alkyl, alkenyl, alkynyl, alkylene, carbocyclyl, aryl, cycloalkyl, heterocyclyl and heteroaryl is optionally and independently substituted. |
