TRANSGENIC MOUSE FOR THE ASSESSMENT OF THYROID HORMONE (TH) ACTION
摘要
A transgenic animal model that is suitable for the cell or tissue specific assessing of thyroid hormone (TH) action in vivo is described. The recombinant DNA construct and methods suitable to generate such an animal are also provided. The assessment of TH action is based on a reporter that is dependent on an endogenously expressed thyroid hormone receptor (TR) and coregulators of said receptor.
申请公布号
WO2016083856(A1)
申请公布日期
2016.06.02
申请号
WO2015HU50020
申请日期
2015.11.30
申请人
MAGYAR TUDOMÁNYOS AKADÉMIA KÍSÉRLETI ORVOSTUDOMÁNYI KUTATÓ INTÉZET
发明人
FEKETE, CSABA;GEREBEN, BALÁZS;MOHÁCSIK, PETRA;ERDÉLYI, FERENC;SZABÓ, GÁBOR