发明名称 |
HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES |
摘要 |
The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject. |
申请公布号 |
WO2015058126(A8) |
申请公布日期 |
2016.06.02 |
申请号 |
WO2014US61206 |
申请日期 |
2014.10.17 |
申请人 |
SYROS PHARMACEUTICALS, INC.;DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
CIBLAT, STEPHANE;DEROY, PATRICK;GRAY, NATHANAEL;LEBLANC, MELISSA;MARINEAU, JASON, J.;MOORE, JOEL;SPROTT, KEVIN;ZHANG, TINGHU;SIDDIQUI, M., ARSHAD;KABRO, ANZHELIKA;LEGER, SERGE;MILLER, TOM;ROY, STEPHANIE;SCHMIDT, DARBY;WINTER, DANA, K.;BRADLEY, MICHAEL |
分类号 |
C07D401/14;A61K31/506;A61P35/02 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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