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1. A polypeptide which binds to the surface of AML blast cells and is internalised upon binding to the AML blast cells comprising an antibody or antibody fragment comprising an amino acid sequence wherein the polypeptide is corresponding to the complementarity determining regions CDR1, CDR2 and CDR3 of the heavy chain of the variable region of an antibody vH having the amino acid sequences for
CDR1: comprising a stretch of 2 polar neutral amino acids, followed by 2 nonpolar neutral amino acids, and followed by a polar neutral amino acid; CDR2 comprising a stretch of 10 amino acids which comprises 2 polar amino acids each with a positive side chain, one polar amino acid with a negative side chain and 1 proline which stretch is linked to a further stretch comprising a polar neutral amino acid, followed by a nonpolar neutral amino acid, followed by a polar amino acid having a negatively charged side chain, followed by a polar neutral amino acid, followed by a nonpolar neutral amino acid followed by a polar amino acid having a positively charged side chain, followed by a nonpolar neutral amino acid; CDR3 comprising a stretch of 7 amino acids wherein the 5th amino acid is nonpolar neutral, followed by a polar amino acid having a negatively charged side chain, followed by a 7th amino acid which is polar neutral. |
