COMPOSITIONS AND METHODS FOR TREATING CONDITIONS RELATED TO EPHRIN SIGNALING WITH CUPREDOXINS AND MUTANTS THEREOF

摘要

The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system in mammalian cells. Specifically, the invention relates to compositions and methods that use cupredoxins, such as azurin, rusticyanin and plastocyanin, and variants, derivatives and structural equivalents thereof, to treat cancer in mammals. The invention specifically includes mutants with altered Eph binding constants and selectivities.

主权项

1. A method for treating a mammalian patient suffering from a pathological condition, the method comprising:
administering to said patient a therapeutically-effective amount of an isolated peptide that is a variant, derivative or structural equivalent of a cupredoxin and that binds an ephrin receptor; wherein one or more of said isolated peptide's amino acids are replaced, deleted or inserted as compared to the wild-type peptide; and wherein the pathological condition is associated with an over-expression or under-expression of an ephrin or an eprhin receptor.