发明名称 |
COMPOSITIONS COMPRISING NECROSIS INHIBITORS, SUCH AS NECROSTATINS, ALONE OR IN COMBINATION, FOR PROMOTING AXON REGENERATION AND NERVE FUNCTION, THEREBY TREATING CNS DISORDERS |
摘要 |
Provided are methods for promoting axon regeneration of a Central Nervous System (CNS) neuron and promoting nerve function following injury to a CNS neuron, for example, brain and/or spinal cord injury. Axon regeneration in a CNS neuron or nerve function following injury to a CNS neuron can be promoted by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject suffering from a CNS disorder, wherein a symptom of the CNS disorder is axon degeneration. |
申请公布号 |
US2016151442(A1) |
申请公布日期 |
2016.06.02 |
申请号 |
US201514930501 |
申请日期 |
2015.11.02 |
申请人 |
MASSACHUSETTS EYE AND EAR INFIRMARY |
发明人 |
Vavvas Demetrios G. |
分类号 |
A61K38/05;A61K38/00;A61K31/4178 |
主分类号 |
A61K38/05 |
代理机构 |
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代理人 |
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主权项 |
1. A method for promoting axon regeneration in a CNS neuron, the method comprising:
exposing the CNS neuron to an effective amount of a necrosis inhibitor and an effective amount of an apoptosis inhibitor thereby to promote the regeneration of the axon. |
地址 |
Boston MA US |