发明名称 |
Reduction of inflammatory disease symptoms by short peptides that inhibit signaling through CD28 |
摘要 |
The present disclosure relates to a method for the treatment of a non-pathogen associated inflammatory disorders in a subject in need thereof, comprising administering to said subject an isolated peptide which specifically binds to an amino acid sequence within the dimer interface of a T cell costimulatory pathway member, particularly the T cell costimulatory pathway members CD28 and CTLA4. The present disclosure also relates to pharmaceutical compositions comprising the isolated peptide and to use of the peptide in treating of a non-pathogen associated inflammatory disorders. |
申请公布号 |
AU2014358677(A1) |
申请公布日期 |
2016.06.02 |
申请号 |
AU20140358677 |
申请日期 |
2014.12.07 |
申请人 |
ATOX BIO LTD.;YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY OF JERUSALEM LTD. |
发明人 |
KAEMPFER, RAYMOND;SHIRVAN, ANAT;ARAD, GILA |
分类号 |
C07K14/705;A61K38/17 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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地址 |
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