| 发明名称 |
COMBINATION THERAPY COMPRISING OX40 BINDING AGONISTS AND TIGIT INHIBITORS |
| 摘要 |
The present invention describes combination therapy comprising an OX40 binding agonist and an agent that decreases or inhibits TIGIT expression and/or TIGIT activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired, such as increasing tumor immunogenicity for the treatment of cancer or chronic infection. |
| 申请公布号 |
US2016152720(A1) |
申请公布日期 |
2016.06.02 |
| 申请号 |
US201514927110 |
申请日期 |
2015.10.29 |
| 申请人 |
Genentech, Inc. |
发明人 |
KIM Jeong M.;GROGAN Jane L. |
| 分类号 |
C07K16/28;C07K16/30 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating or delaying progression of cancer in an individual comprising administering to the individual an effective amount of an OX40 binding agonist and an agent that decreases or inhibits TIGIT expression and/or activity. |
| 地址 |
South San Francisco CA US |
