METHODS AND DEVICE TO NEUTRALIZE SOLUBLE TOXIC AGENTS IN THE BRAIN

摘要

Methods, agents and devices for treating a patient to reduce accumulation of certain proteins in the brain are described. Such proteins include amyloid beta (Aβ), and the methods, agents and devices are useful for reducing the accumulation of Aβ, which is a principal constituent of the plaques associated with such diseases as Alzheimer's disease (AD). Antibodies to Aβ, when delivered systemically or directly into the central nervous system, improve cognitive deficits in a transgenic mouse model of AD. However, unlike peripheral antibodies to Aβ, which increased cerebral vascular plaques and hemorrhages, direct central administration did not result in such an increase cerebral vascular plaques and hemorrhages.

主权项

1. A method for treating a subject having a cerebral vascular disease associated with increased or aberrant soluble amyloid beta (Aβ), amyloid fibrils, or amyloid plaques, comprising:
chronically delivering to a cerebral ventricle of the subject an anti-Aβ antibody in an amount effective to treat the disease, wherein the anti-Aβ antibody is chronically delivered to the subject's cerebral ventricle from a reservoir of an implantable infusion device.