ACTIVE CXCR4+ IMMUNE CELLS AND METHODS FOR THEIR PRODUCTION AND USE

摘要

Provided herein are active CXCR4+ CD8+ T cells, active CXCR4+ type-I CD4+ T cells and active CXCR4+ NK cells and populations of those cells, methods for making active CXCR4+ T cells and NK cells and populations of those cells based upon exposure to hypoxic conditions, and methods for using active CXCR4+ T cells and NK cells and populations of those cells for the treatment of cancer, precancerous conditions and chronic infections.