发明名称 |
Transdermal administration of tamsulosin |
摘要 |
In an aspect of the invention, a composition for making a patch for the transdermal delivery of tamsulosin is provided. The composition comprises (a) at least about 1 wt% tamsulosin or a pharmaceutically acceptable salt of tamsulosin, (b) at least about 40 wt% polyisobutylene adhesive or hydrophobic synthetic rubber adhesive, (c) about 1 -20 wt% of an aprotic solvent in which tamsulosin dissolves readily, (d) about 1-20 wt% of an unsaturated fatty acid or an alpha-hydroxy acid or a mixture of unsaturated fatty acids or alpha-hydroxy acids or of both unsaturated fatty acids and alpha-hydroxy acids, (e) a lipophilic permeation enhancer, and (f) a matrix modifier. |
申请公布号 |
AU2010204986(B2) |
申请公布日期 |
2016.06.02 |
申请号 |
AU20100204986 |
申请日期 |
2010.01.14 |
申请人 |
CORIUM INTERNATIONAL, INC. |
发明人 |
SINGH, PARMINDER;LEE, EUN SOO;JAIN, AMIT K. |
分类号 |
A61K9/70;A61K31/137;A61K31/18;A61K47/06 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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