发明名称 |
Monovalent antigen binding constructs targeting EGFR and/or HER2 and uses thereof |
摘要 |
Provided herein are monovalent antigen-binding constructs targeting EGFR and/or HER2. The monovalent antigen-binding constructs can include at least one antigen-binding polypeptide comprising a heavy chain variable domain, wherein the antigen-bind polypeptide specifically binds EGFR and/or HER2; and a heterodimeric Fc domain, the Fc domain comprising at least two CH3 domains, wherein the Fc domain is coupled, with or without a linker, to the antigen-binding polypeptide. Also provided are methods of making the constructs and methods of using the constructs. |
申请公布号 |
AU2014348552(A1) |
申请公布日期 |
2016.06.02 |
申请号 |
AU20140348552 |
申请日期 |
2014.11.13 |
申请人 |
ZYMEWORKS INC. |
发明人 |
CHAN, PETER WING YIU;NG, GORDON YIU KON;WICKMAN, GRANT RAYMOND |
分类号 |
C12P21/08;A61K39/00;C12N5/07;C12P21/06 |
主分类号 |
C12P21/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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