Biomarkers for Increased Risk of Drug-Induced 5-Aminosalicylate Nephrotoxicity

摘要

The present invention provides a method for predicting the risk of a patient for developing adverse drug reactions, particularly 5-aminosalicylate nephrotoxicity (5-ASA nephrotoxicity). The invention also provides a method of identifying a subject afflicted with, or at risk of, developing 5-ASA nephrotoxicity. In some aspects, the methods comprise analyzing at least one genetic marker, wherein the presence of the at least one genetic marker indicates that the subject is afflicted with, or at risk of, developing 5-ASA nephrotoxicity.

主权项

1. A method of identifying a subject afflicted with, or at risk of developing, 5-aminosalicylate nephrotoxicity (5-ASA nephrotoxicity) comprising:
(a) obtaining a nucleic-acid containing sample from the subject; and (b) analyzing the sample to detect the presence of at least one genetic marker, or an equivalent to at least one genetic marker, selected from those in Table 1, wherein the presence of at least genetic marker, or an equivalent to at least one genetic marker, from Table 1 in the sample indicates that the subject is afflicted with, or at risk of, developing 5-ASA nephrotoxicity.