MULTIPLEXED PATHLENGTH RESOLVED NONINVASIVE ANALYZER APPARATUS WITH DYNAMIC OPTICAL PATHS AND METHOD OF USE THEREOF

摘要

A noninvasive analyzer apparatus and method of use thereof is described comprising a near-infrared source, a detector, and a photon transport system configured to direct photons from the source to the detector via an analyzer-sample optical interface. The photon transport system includes a dynamically position light directing unit used to, within a measurement time period for a single analyte concentration determination, change any of: radius, energy, intensity, position, incident angle, solid angle, and/or depth of penetration of a beam of photons entering skin of a subject.

主权项

1. A method for noninvasively determining an analyte concentration of a person, comprising the steps of:
providing a near-infrared analyzer, comprising:
at least one near-infrared source;a detector; anda photon transport system configured to direct photons from said source, via a sample illumination zone, to said detector via both a detection zone and a face of an analyzer-sample optical interface; dynamically changing, within a time window of data collection for a single analyte concentration determination, a mean radial illumination position of incident light from said near-infrared source relative to a center of the detection zone of said analyzer-sample optical interface, said step of dynamically changing further comprising:
directing the photons, during a first time period of the time window, to a first arc of illumination optics at a first range of radial distances from the detection zone; anddirecting the photons, during a second time period of the time window, to a second arc of illumination optics at a second range of radial distances from the detection zone,wherein at said analyzer-sample optical interface none of said first range of radial distances overlap any of said second range of radial distances.