发明名称 |
A NANOSPHERE - HISTONE ACETYLTRANSFERASE (HAT) ACTIVATOR COMPOSITION, PROCESS AND METHODS THEREOF |
摘要 |
The present invention is in relation to a composition including nanosphere and histone acetyltransferase (HAT) activator. The nanosphere is carbon nanosphere (CSP) which is intrinsically fluorescent and the HAT activator is N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide. The N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide is covalently conjugated with the carbon nanosphere. The present invention further relates to a process for obtaining a composition including carbon nanosphere and Histone acetyltransferase (HAT) activator [N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide]. The composition is capable of crossing blood brain barrier and inducing histone acetylation in brain. Further, the composition is capable of increasing neurogenesis, as well as improving long-term memory formation. The composition manages pathological conditions to a subject in need thereof, such as aging-related, neurodegenerative diseases (Alzheimer's in particular), neurological disorders, depression or other kinds of diseases in which increased HAT activity, neurogenesis and/or memory improvement would benefit. |
申请公布号 |
EP2841111(B1) |
申请公布日期 |
2016.06.01 |
申请号 |
EP20130731163 |
申请日期 |
2013.04.27 |
申请人 |
JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH;UNIVERSITÉ DE STRASBOURG |
发明人 |
KUNDU, TAPAS KUMAR;BOUTILLIER, ANNE-LAURENCE;CHATTERJEE, SNEHAJYOTI;ESWARAMOORTHY, MUTHUSAMY;MIZAR, PUSHPAK;MATHIS, CHANTAL;CASSEL, JEAN-CHRISTOPHE;NEIDL, ROMAIN;VASUDEVARAO, MOHANKRISHNA DALVOY;MAHESHWARAPPA, VEDAMURTHY BHUSAINAHALLI |
分类号 |
A61K47/48;A61K31/167;A61K49/00;A61P25/28 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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