| 发明名称 | Bi-functional short-hairpin RNA (bi-shRNA) specific for single-nucleotide <i>KRAS </i>mutations | ||
| 摘要 | The present invention includes compositions and methods for making and using a bifunctional shRNAs capable of reducing an expression of a K-ras gene, e.g., a mutated K-ras gene, wherein at least one target site sequence of the bifunctional RNA molecule is located within the K-ras gene and wherein the bifunctional RNA molecule is capable of activating a cleavage-dependent and a cleavage-independent RNA-induced silencing complex for reducing the expression level of K-ras. | ||
| 申请公布号 | US9353373(B2) | 申请公布日期 | 2016.05.31 |
| 申请号 | US201313890957 | 申请日期 | 2013.05.09 |
| 申请人 | STRIKE BIO, INC. | 发明人 | Rao Donald;Wang Zhaohui;Nemunaitis John J.;Senzer Neal |
| 分类号 | C12N15/113;A61K31/713;A61K45/06;C12Q1/68 | 主分类号 | C12N15/113 |
| 代理机构 | Chalker Flores, LLP | 代理人 | Chalker Flores, LLP ;Flores Edwin S. |
| 主权项 | 1. A bifunctional shRNAs capable of reducing an expression of a mutated K-ras gene, wherein at least one target site sequence of the bifunctional RNA molecule is located within the K-ras gene and wherein the bifunctional RNA molecule is capable of activating a cleavage-dependent and a cleavage-independent RNA-induced silencing complex for reducing the expression level of mutated K-ras, without reducing normal K-ras expression, wherein the bifunctional shRNA comprises the sequence of SEQ ID NO: 56. | ||
| 地址 | Dallas TX US | ||