| 摘要 |
This invention is directed to a compound of Formula I;
or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, and X are as defined herein. The compounds of Formula I are useful as receptor tyrosine kinase (RTK) inhibitors and can be used to treat such diseases as cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders and metabolic diseases. |
| 主权项 |
1. A compound represented by Formula I or an enatiomer, diastereoisomer or pharmaceutically acceptable salt thereof:wherein:
R1 is substituted or unsubstituted heterocycle or substituted or unsubstituted aryl; X is R2 is substituted or unsubstituted heterocycle or substituted or unsubstituted aryl; R3 is hydrogen, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, halogen, hydrogen, (CR8R9)aC(O)OR10, (CR8R9)aOR10, (CR8R9)aN(R11)C(O)OR10, (CR8R9)aC(O) N(R11R12)2, (CR8R9)aN(R11)C(O)OR10, (CR8R9)aN(R11)C(O)N(R11R12)2 or (CR8R9)aN(R11R12)2; R4 is hydrogen, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, halogen, hydrogen, (CR8R9)aC(O)OR10, (CR8R9)aOR10, (CR8R9)aN(R11)C(O)OR10, (CR8R9)aC(O) N(R11R12)2, (CR8R9)aN(R11)C(O)OR10, (CR8R9)aN(R11)C(O)N(R11R121)2 or (CR8R9)aN(R11R12)2; R5 is hydrogen, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, halogen, hydrogen, (CR8R9)aC(O)OR10, (CR8R9)aOR10, (CR8R9)aN(R11)C(O)OR10, (CR8R9)aC(O) N(R11R121)2, (CR8R9)aN(R11)C(O)OR10, (CR8R9)aN(R11)C(O)N(R11R12)2 or (CR8R9)aN(R11R12)2; R6 is hydrogen, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, halogen, hydrogen, (CR8R9)aC(O)OR10, (CR8R9)aOR10, (CR8R9)aN(R11)C(O)OR10, (CR8R9)aC(O)N(R11R121)2, (CR8R9)aN(R11)C(O)OR10, (CR8R9)aN(R11)C(O)N(R11R12)2 or (CR8R9)aN(R11R12)2; R7 is hydrogen, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, halogen, hydrogen, (CR8R9)aC(O)OR10, (CR8R9)aOR10, (CR8R9)aN(R11)C(O)OR10, (CR8R9)aC(O)N(R11R121)2, (CR8R9)aN(R11)C(O)OR10, (CR8R9)aN(R11)C(O)N(R11R12)2 or (CR8R9)aN(R11R12)2; R8 is substituted or unsubstituted C1-8 alkyl, hydrogen, fluoro, —CH2OH, —OH, COCH3, CH2CH2OH, CH2CH2CH2OH or CH2CH2OCH2CH2OH; R9 is substituted or unsubstituted C1-8 alkyl, hydrogen, fluoro or —OH; R10 is substituted or unsubstituted C1-8 alkyl or hydrogen; R11 is substituted or unsubstituted C1-8 alkyl, hydrogen or can form together with the N and R12 a substituted or unsubstituted heterocycle; R12 is substituted or unsubstituted C1-8 alkyl, hydrogen or can form together with the N and R11 a substituted or unsubstituted heterocycle; and a is 0, 1, 2, 3 or 4. |
