| 主权项 |
1. A compound of the formula I, in any of its stereoisomeric forms or a physiologically acceptable salt thereof, or a physiologically acceptable solvate thereof,wherein Ht is G is selected from the group consisting of R71—O—C(O)—, R72—N(R73)—C(O)—, NC— and tetrazol-5-yl; R3 is hydrogen or (C1-C6)-alkyl; R4 is selected from the group consisting of (C1-C7)-alkyl, (C3-C7)-cycloalkyl-CsH2s— and Ar—CsH2s—, wherein s is independently 0, 1, 2 or 3; R10 is selected from the group consisting of hydrogen, (C3-C7)-cycloalkyl, Ar, Het3, Het2 —C(O)—, R14—C(O)— and (C1-C4)-alkyl-S(O)m—; R14 is (C1-C10)-alkyl which is optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, HO—, R16—O—, oxo, (C3-C7)-cycloalkyl, Ar, Het1,Het3, NC—, H2N—C(O)—, (C1-C4)-alkyl-NH—C(O)—, di((C1-C4)-alkyl)N—C(O)—, Het1, —C(O)—, (C1-C4)-alkyl-C(O)—NH— and (C1-C4)-alkyl-S(O)m—; R16 is (C1-C6)-alkyl which is optionally substituted by one or more identical or different substituents selected from the group consisting of HO—, (C1-C4)-alkyl-O— and NC—; R30 is selected from the group consisting of R31, (C3-C7)-cycloalkyl, R32—CuH2u— and Het3-CuH2u —, wherein u is independently 0, 1, 2 or 3; R31 is (C1-C10)-alkyl which is substituted by one or more identical or different substituents selected from the group consisting of halogen, (C3-C7)-cycloalkyl, HO—, (C1-C6)-alkyl-O—, (C1-C6)-alkyl-S(O)m— and NC—; R32 is selected from the group consisting of phenyl and an aromatic 5-membered or 6-membered monocyclic heterocycle containing one, two or three identical or different ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur and bonded via a ring carbon atom, wherein the phenyl and the heterocycle are optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, HO—, (C1-C6)-alkyl-O—, R33—O—, R33—(C1-C4)-alkyl-O—, —O—CH2—O—, —O—CF2—O—, (C1-C6)-alkyl-S(O)m—, H2N—S(O)2—, (C1-C4)-alkyl-NH—S(O)2—, di((C1-C4)-alkyl)N—S(O)2—, H2N—, (C1-C6)-alkyl-NH—, di((C1-C6)-alkyl)N—, Het1,(C1-C4)-alkyl-C(O)—NH—, Ar—C(O)—NH—, (C1-C4)-alkyl-S(0)2—NH— and NC—; R33 is selected from the group consisting of phenyl and an aromatic 5-membered or 6-membered monocyclic heterocycles containing one, two or three identical or different ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and bonded via a ring carbon atom, wherein the phenyl and the heterocycle are optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, HO—, (C1-C6)-alkyl-O—, (C1-C6)-alkyl-S(O)m—, H2N—S(O)2—, (C1-C4)-alkyl-NH—S(O)2—, di((C1-C4)-alkyl)N—S(O)2— and NC—; R40 is hydrogen or (C1-C4)-alkyl; or R30 and R40 together are (CH2)x, which is optionally substituted by one or more identical or different (C1-C4)-alkyl substituents, wherein x is independently 2, 3, 4 or 5; R50 is selected from the group consisting of hydrogen, (C1-C6)-alkyl, HO— and (C1-C6)-alkyl-O—; R60 is selected from the group consisting of hydrogen and (C1-C6)-alkyl; or R50 and R60 together are (CH2)y, which is optionally substituted by one or more identical or different (C1-C4)-alkyl substituents, wherein y is independently 2, 3, 4 or 5; or R30 and R50 together are (CH2)z, which is optionally substituted by one or more identical or different (C1-C4)-alkyl substituents, wherein z is independently 2, 3, 4 or 5; R71 is hydrogen or (C1-C8)-alkyl, which is optionally substituted by one or more identical or different substituents selected from the group consisting of (C1-C6)-alkyl-O— and (C1-C6)-alkyl-C(O)—O—; R72 is selected from the group consisting of hydrogen, (C1-C6)-alkyl, (C3-C6)-cycloalkyl, —CH2—(CH2)b—(C3-C6)-cycloalkyl, Het4 and —(CH2)b-Het4, wherein alkyl or cycloalkyl is optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, HO—, HOOC—, (C1-C6)-alkyl-O— and (C1-C6)-alkyl-C(O)—O—, NC—, —N((C1-C4)-alkyl)2, and b is 0, 1 or 2; R73 is selected from the group consisting of hydrogen and (C1-C6)-alkyl; or R72 and R73 together with the nitrogen atom to which they are bonded form a saturated 4-membered to 7-membered monocyclic heterocycle, which optionally contains one further ring heteroatom selected from the group consisting of nitrogen, oxygen and sulfur, and which is optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, (C1-C4)-alkyl, HO— and (C1-C4)-alkyl-O—; Ar, independently of each other group Ar, is selected from the group consisting of phenyl and aromatic 5-membered or 6-membered monocyclic heterocycles containing one, two or three identical or different ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and bonded via a ring carbon atom, wherein the phenyl and the heterocycle are optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, (C1-C6)-alkyl, (C1-C6)-alkyl-O—, —O—CH2—O—, O—CH2—CH2—O—, —O—CF2—O—, (C1-C6)-alkyl-S(O)m—, H2N—S(O)2—, CF3 and NC—; Het1, independently of each other group Het1, is a saturated or unsaturated 4-membered to 8-membered monocyclic heterocycle containing a ring nitrogen atom via which Het1 is bonded, and optionally, one or two identical or different further ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and which is optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, (C1-C4)-alkyl, HO—, (C1-C4)-alkyl-O—, oxo and NC—; Het2 is a saturated 4-membered to 7-membered monocyclic heterocycle containing a ring nitrogen atom via which Het2 is bonded, and optionally, one further ring heteroatom selected from the group consisting of nitrogen, oxygen and sulfur, and which is optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, (C1-C4)-alkyl, HO—, oxo and (C1-C4)-alkyl-O—; Het3, independently of each other group Het3, is a saturated 4-membered to 7-membered monocyclic heterocycle containing one or two identical or different ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and is bonded via a ring carbon atom, and which is optionally substituted by one or more identical or different substituents selected from the group consisting of fluorine, (C1-C4)-alkyl and oxo; Het4, independently of each other group Het4, is a saturated or unsaturated 4-membered to 8-membered monocyclic heterocycle containing one to four ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and which is optionally substituted by one or more identical or different substituents selected from the group consisting of halogen, (C1-C4)-alkyl, HO—, (C1-C4)-alkyl-O—, oxo and NC—; m, independently of each other number m, is 0, 1 or 2; wherein all cycloalkyl groups, independently of each other, are optionally substituted by one or more identical or different substituents selected from the group consisting of fluorine and (C1-C4)-alkyl; and wherein all alkyl, CsH2s, CuH2u,(CH2)x and (CH2)y groups, independently of each other, and independently of any other substituents, are optionally substituted by one or more fluorine substituents. |
