发明名称 |
Process for preparation of isosulfan blue |
摘要 |
A process for the preparation of isosulfan blue (Active Pharmaceutical Ingredient) is provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2,5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon mild oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater. |
申请公布号 |
US9353050(B2) |
申请公布日期 |
2016.05.31 |
申请号 |
US201113310019 |
申请日期 |
2011.12.02 |
申请人 |
Apicore US LLC |
发明人 |
Kovi Ravishanker;Nampalli Satyam;Tharial Peter Xavier |
分类号 |
C07C303/02;C07C303/22 |
主分类号 |
C07C303/02 |
代理机构 |
Gibson & Dernier LLP |
代理人 |
Gibson Timothy X.;Gibson & Dernier LLP |
主权项 |
1. A compound N-[4-[[4-(diethyl amino)phenyl](2,5-disulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-N-ethylethanaminium, sodium salt having a purity of at least 99.0% by HPLC. |
地址 |
Somerset NJ US |