发明名称 |
processo de granulação e granulados assim preparados |
摘要 |
The present invention relates to a process for manufacturing microcrystalline ezetimibe containing granulate, wherein a) ezetimibe is dissolved; b) the dissolved ezetimibe is precipitated with water, which if necessary contains pharmaceutical excipients, preferably lauryl-sulfate derivatives, and c) granulates are formed from the obtained suspension by spraying the suspension onto pharmaceutical excipients. A further aspect of the present invention is the granulate obtained by the present process and the pharmaceutical composition containing such granulate. |
申请公布号 |
BR112012002069(A2) |
申请公布日期 |
2016.05.31 |
申请号 |
BR20121102069 |
申请日期 |
2010.02.24 |
申请人 |
EGIS GYÓGYSZERGYÁR NYILVÁNOSAN MÛKÖDÕ RÉSZVÉNYTÁRSASÁG |
发明人 |
GYÖRGY ÚJFALUSSY;MAGDOLNA LEVENTISZNÉ HUSZÁR;MÓNIKA AGYAGOS;PÉTER TONKA-NAGY;ZOLTÁN TÖLGYESI;ZSOLT ZSIGMOND |
分类号 |
A61K9/16;A61K9/20;A61K9/50;A61K31/397;A61K45/06 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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