发明名称 |
METHOD OF USING DIKETOPIPERAZINES AND COMPOSITION CONTAINING THEM |
摘要 |
The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of formula (1) wherein R1 and R2 are defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds. |
申请公布号 |
CA2774959(C) |
申请公布日期 |
2016.05.31 |
申请号 |
CA20012774959 |
申请日期 |
2001.08.02 |
申请人 |
DMI BIOSCIENCES, INC. |
发明人 |
BAR-OR, DAVID;CURTIS, C. GERALD;RAO, NAGARAJA K. R.;THOMAS, GREG |
分类号 |
A61K38/05;A61K31/495;A61K31/496;A61P7/02;A61P11/00;A61P11/06;A61P27/14;A61P29/00;A61P31/00;A61P31/04;A61P37/08;A61P43/00 |
主分类号 |
A61K38/05 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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