CONTROLLED RELEASED CARVEDIOLOL FORMULATION

摘要

A CONTROLLED RELEASE CARVEDILOL FORMULATION FOR LESS FREQUENT, PREFERABLY ONCE DAILY ADMINISTRATION IS DESCRIBED. THE CONTROLLED RELEASE FORMULATION COMPRISES A THERAPEUTICALLY EFFECTIVE AMOUNT OF CARVEDILOL OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, A MATRIX FORMING POLYMER, A SOLUBILITY ENHANCER AND A PHARMACEUTICALLY ACCEPTABLE CARRIER. IN ONE EMBODIMENT, A CONTROLLED RELEASE FORMULATION HAVING A THERAPEUTICALLY EFFECTIVE AMOUNT OF CARVEDILOL IS CONTAINED IN TWO OR MORE SUBUNITS HAVING DIFFERENT RELEASE PROFILES. THE CONTROLLED RELEASE FORMULATION IS USABLE IN THE TREATMENT AND/OR PROPHYLAXIS OF ONE OR MORE CONDITIONS SUCH AS CARDIOVASCULAR DISORDERS.