发明名称 |
Apelin fusion proteins and uses thereof |
摘要 |
The invention provides a fusion protein or polypeptide comprising an apelin peptide fused to a multimerizing component. The invention also provides a fusion protein or polypeptide comprising an apelin peptide fused to an Fc domain, a fragment of an Fc domain, or a variant of an Fc domain. Apelin Fc-fusion polypeptides are capable of binding to the apelin receptor (APLNR). Apelin Fc-fusion polypeptides are capable of activating the APLNR and have improved pharmacokinetic properties compared to apelin peptides that are not fused to an Fc or an Fc fragment. Apelin Fc-fusion polypeptides are useful in diseases and conditions related to cardiovascular function, diabetes, cancer, obesity and other apelin-related conditions. |
申请公布号 |
US9353163(B2) |
申请公布日期 |
2016.05.31 |
申请号 |
US201414212753 |
申请日期 |
2014.03.14 |
申请人 |
Regeneron Pharmaceuticals, Inc. |
发明人 |
Stevis Panayiotis;Murphy Andrew |
分类号 |
A61K39/00;C12N5/07;C12N15/00;C12P21/08;C07H21/04;C07K14/435;C07K14/47;A61K38/00 |
主分类号 |
A61K39/00 |
代理机构 |
Alston & Bird LLP |
代理人 |
Alston & Bird LLP ;Johnson Mary C. |
主权项 |
1. A polypeptide comprising the amino acid sequence of SEQ ID NO: 2. |
地址 |
Tarrytown NY US |