Crystal form of asenapine maleate, a method for the preparation thereof, pharmaceutical composition comprising it, uses thereof in the preparation of pharmaceutical formulations for the treatment of mental disorders such as schizophrenia or bipolar disorder and microcrystalline form thereof

摘要

The invention relates to an orthorhombic crystal form of compound trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz [2,3:6,7] oxepino [4,5-c] pyrrole (Z)-2-butenedioate, to methods for the preparation of this crystal form and to pharmaceutical compositions comprising an orthorhombic crystal form.