发明名称 Methods for treating cancer and non-neoplastic conditions
摘要 Compounds, such as compounds of Formula (I), that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.;
申请公布号 US9351964(B2) 申请公布日期 2016.05.31
申请号 US201013321257 申请日期 2010.05.27
申请人 PTC Therapeutics, Inc. 发明人 Almstead Neil;Arasu Tamil;Choi Soongyu;Cao Liangxian;Campbell Jeffrey Allen;Corson Donald;Davis Thomas W.;Graci Jason D.;Gu Zhengxian;Hwang Peter Seongwoo;Lennox William;Miao Harry H.;Miller Langdon;Moon Young-Choon;Qi Hongyan;Trotta Christopher;Weetall Marla L.
分类号 A01N43/04;A61K31/44;A61K45/06;A61K31/4745;A61K31/437;C07D471/04 主分类号 A01N43/04
代理机构 Jones Day 代理人 Jones Day
主权项 1. A compound having the formula: or a pharmaceutically acceptable salt, racemate or stereoisomer thereof.
地址 South Plainfield NJ US