| 发明名称 | Dicarboxylic acid production process | ||
| 摘要 | The present invention relates to a process for the production of a dicarboxylic acid and ethanol which comprises fermenting a genetically modified yeast in a suitable fermentation medium under anaerobic conditions at a pH value of between 1 and 5 and producing the dicarboxylic acid and ethanol. The invention also relates to a process for crystallizing succinic acid from an aqueous solution having a pH of between 1 and 5 and comprising succinic acid, comprising removing part of the aqueous solution by evaporation to obtain a concentrated solution, and bringing the temperature of the concentrated solution to a value of between 10 and 30 degrees Celsius, wherein succinic acid crystals are formed. | ||
| 申请公布号 | US9353387(B2) | 申请公布日期 | 2016.05.31 |
| 申请号 | US201013260691 | 申请日期 | 2010.03.23 |
| 申请人 | DSM IP ASSETS B.V. | 发明人 | Jansen Mickel Leonardus August;Van de Graaf Maarten Job;Verwaal René |
| 分类号 | C12P7/46 | 主分类号 | C12P7/46 |
| 代理机构 | McBee Moore Woodward & Vanik IP, LLC | 代理人 | McBee Moore Woodward & Vanik IP, LLC |
| 主权项 | 1. A process for the production of a dicarboxylic acid and ethanol which comprises fermenting a genetically modified yeast in a fermentation medium under anaerobic conditions at a pH value of between 1 and 5 and producing the dicarboxylic acid and ethanol, wherein the dicarboxylic acid is selected from the group consisting of: malic acid, fumaric acid, and succinic acid, and wherein the genetically modified yeast is transformed with at least one nucleotide encoding an enzyme expressed in the cytosol selected from the group consisting of: phosphoenol pyruvate carboxykinase, malate dehydrogenase, fumarase, and fumarate reductase. | ||
| 地址 | Heerlen NL | ||