发明名称 |
profármacos compreendendo um conjugado ligador de insulina |
摘要 |
The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof comprising an insulin linker conjugate D-L, wherein D represents the insulin moiety; and -L is a non-biologically active linker moiety -L1 represented by formula (I), wherein the dashed line indicates the attachment to one of the amino groups of the insulin by forming an amide bond. The invention further relates to pharmaceutical compositions comprising said prodrugs as well as their use as a medicament for treating or preventing diseases or disorders which can be treated by insulin. |
申请公布号 |
BR112012002168(A2) |
申请公布日期 |
2016.05.31 |
申请号 |
BR20121102168 |
申请日期 |
2010.07.30 |
申请人 |
SANOFI-AVENTIS DEUTSCHLAND GMBH |
发明人 |
FELIX CLEEMANN;HARALD RAU;SILVIA KADEN-VAGT;THOMAS WEGGE;TORBEN LESSMANN;ULRICH HERSEL |
分类号 |
A61K38/28;A61K47/48;A61P3/10;C07K14/62 |
主分类号 |
A61K38/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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