Compositions and methods of enhancing wound healing

摘要

The present invention relates to ionic compositions for enhancing wound healing, particularly in the sinonasal cavity. The ionic components of the composition can include potassium, calcium, rubidium, zinc, bromide, and magnesium in an isotonic solution. In other embodiments, the ionic components of the composition can include magnesium, bromide, sulfate, sodium, and chloride. Methods of enhancing wound healing, enhancing sinonasal mucosal healing, promoting mucosal reciliation, and debriding tissue by administering the compositions of the present invention are also presented.

主权项

1. A sterile isotonic solution for enhancing wound healing in mucosal tissues in a mammalian subject consisting essentially of:
a therapeutically effective amount of potassium ions; a therapeutically effective amount of rubidium ions; a therapeutically effective amount of calcium ions; a therapeutically effective amount of zinc ions; a therapeutically effective amount of magnesium ions; a therapeutically effective amount of bromide ions; a therapeutically effective amount of counterions wherein the counterions are selected from the group consisting of citrate, chloride, bromide, sulfate, hydroxide, bicarbonate, carbonate, phosphate, lactate, glutamate, acetate and combinations thereof; and a pharmaceutically acceptable carrier; wherein tonicity of the solution is 0.9%.