Patch and patch preparation

摘要

The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 1,700,000-6,500,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.

主权项

1. A patch comprising a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer comprises poly(2-methylpropene) having a viscosity average molecular weight of 4,000,000-6,500,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate,
wherein the magnesium aluminometasilicate comprises an amorphous composite oxide of the formula:
Al2O3/aMgO/bSiO2·nH2O, wherein a is 0.3-3 and b is 0.3-5, the total content of magnesium aluminometasilicate in the adhesive layer is less than 25 wt % relative to the total weight of the adhesive layer, and the organic fluid component having high polarity has an angle within the range of 20°-80° as calculated by the following formula using an inorganic value and an organic value in an organic conceptual diagram:
Angle[°]=arc tan(organic value/inorganic value)−1×(180/π).