Antiviral drugs for treatment or prevention of dengue infection

摘要

Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.

主权项

1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected from the group consisting of N-(4-Diethylsulfamoyl-phenyl)-2-(4-oxo-4H-quinazolin-3-yl)-acetamide; N-(5-Diethylsulfamoyl-2-methoxy-phenyl)-isobutyramide; N-(4-Diethylsulfamoyl-phenyl)-2-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl)-acetamide; N-(4-Diethylsulfamoyl-phenyl)-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetamide; N-(4-Diethylsulfamoyl-phenyl)-2-(4-oxo-4H-thieno[2,3-d]pyrimidin-3-yl)-acetamide; N-(4-Diethylsulfamoyl-phenyl)-2-(1,4-dioxo-3,4-dihydro-1H-phthalazin-2-yl)-acetamide; N-(4-Diethylsulfamoyl-phenyl)-2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-acetamide; N-(4-Diethylsulfamoyl-phenyl)-2-(5,6-dimethyl-4-oxo-4H-thieno[2,3-d]pyrimidin-3-yl)-acetamide; N-(4-Diethylsulfamoyl-phenyl)-2-(6-ethyl-4-oxo-4H-thieno[2,3-d]pyrimidin-3-yl)-acetamide; N-(5-Diethylsulfamoyl-2-methyl-phenyl)-2-(7-nitro-4-oxo-4H-quinazolin-3-yl)-acetamide; N-(5-Diethylsulfamoyl-2-methoxy-phenyl)-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetamide; N-(5-Diethylsulfamoyl-2-methoxy-phenyl)-butyramide; N-(5-Diethylsulfamoyl-2-methoxy-phenyl)-3-methyl-butyramide; N-(5-Diethylsulfamoyl-2-methoxy-phenyl)-2-phenyl-acetamide; 1-[2-(4-oxo-4H-quinazolin-3-yl)-acetyl]-2,3-dihydro-1H-indole-5-sulfonic acid diethylamide; N-(5-Diethylsulfamoyl-2-methoxy-phenyl)-2-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl)-acetamide; Pentanoic acid (5-diethylsulfamoyl-2-methoxy-phenyl)-amide; N-(4-Diethylsulfamoyl-phenyl)-2-(4-oxo-4H-thieno[3,2-d]pyrimidin-3-yl)-acetamide; 2-(7-Chloro-4-oxo-4H-quinazolin-3-yl)-N-(4-diethylsulfamoyl-phenyl)-acetamide; N-(4-Diethylsulfamoyl-phenyl)-2-(4-oxo-4H-benzo[4,5]furo[3,2-d]pyrimidin-3-yl)-acetamide; N-(5-Diethylsulfamoyl-2-isopropoxy-phenyl)-3-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl)-propionamide; N-(4-Diethylsulfamoyl-phenyl)-2-(8-methyl-4-oxo-4H-quinazolin-3-yl)-acetamide; N-(5-Diethylsulfamoyl-2-methoxy-phenyl)-3-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl)-propionamide; and N-(4-Diethylsulfamoyl-phenyl)-2-[ethyl-(4-oxo-3,4-dihydro-quinazolin-2-ylmethyl)-amino]-acetamide; wherein said pharmaceutical composition is suitable for administration in a human or animal and wherein said pharmaceutically acceptable carrier is selected form the group consisting of, dispersion aids, suspension aids, surface active agents, isotonic agents, thickening agents, emulsifying agents, preservatives, solid binders and lubricants.