| 发明名称 | Selectively targeted antimicrobial peptides and the use thereof | ||
| 摘要 | The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e.g., P. aeruginosa or S. mutans), antimicrobial peptides having antimicrobial activities, and specifically/selectively targeted antimicrobial peptides (STAMPs). In addition, the present invention provides methods of selectively killing or inhibiting microbial organisms by using the peptides or compositions provided by the present invention. | ||
| 申请公布号 | US9351490(B2) | 申请公布日期 | 2016.05.31 |
| 申请号 | US201414178061 | 申请日期 | 2014.02.11 |
| 申请人 | The Regents of the University of California | 发明人 | Eckert Randal H.;Yarbrough Daniel K.;Shi Wenyuan;Anderson Maxwell H.;Qi Fengxia;He Jian;McHardy Ian H. |
| 分类号 | A01N37/46;C07K7/06;C07K7/08;C07K14/315;C07K14/00;A61K38/00 | 主分类号 | A01N37/46 |
| 代理机构 | Gates & Cooper LLP | 代理人 | Gates & Cooper LLP |
| 主权项 | 1. A method of selectively killing a Streptococcus mutans, said method comprising contacting said S. mutans with an amount of a construct effective to kill an S. mutans, wherein said construct comprises a targeting peptide that binds Streptococcus mutans, the amino acid sequence of said peptide consisting of the sequence TFFRLFNRSFTQALGK (SEQ ID NO:2) attached to a an antimicrobial peptide. | ||
| 地址 | Oakland CA US | ||