| 发明名称 | Preparation method for rivastigmine, intermediates thereof, and preparation method for said intermediates | ||
| 摘要 | The present invention provides a preparation method for (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate, preparation methods for intermediates (S)-1-(3-methoxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium, (S)-1-(3-hydroxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium and (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium, as well as a method for using (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium to prepare rivastigmine which can be used for the treatment of Alzheimer's disease. | ||
| 申请公布号 | US9353049(B2) | 申请公布日期 | 2016.05.31 |
| 申请号 | US201214118411 | 申请日期 | 2012.05.16 |
| 申请人 | Zhejiang Hisun Pharmaceutical Co., Ltd.;Shanghai Institute of Pharmaceutical Industry | 发明人 | Zhang Fuli;Yang Zhezhou;Yang Chunbo;Chen Daoxin;Yang Zhiqing;Sun Rentong;Bai Hua |
| 分类号 | C07C269/04;C07C269/06;C07C271/44;C07C215/66;C07C217/58;C07C309/04 | 主分类号 | C07C269/04 |
| 代理机构 | Ladas & Parry LLP | 代理人 | Ladas & Parry LLP |
| 主权项 | 1. A compound corresponding to Formula IX:wherein Y is selected from the group consisting of SO4CH3, CO3CH3, SO3CF3, SO3F, Cl, Br, and I. | ||
| 地址 | Zhejiang CN | ||