Ventilation circuit adaptor and proximal aerosol delivery system

摘要

An adaptor for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation includes an aerosol flow channel having an aerosol inlet port and a patient interface port, and defining an aerosol flow path from the aerosol inlet port to and through the patient interface port; and a ventilation gas flow channel in fluid communication with the aerosol flow channel and having a gas inlet port and a gas outlet port, and defining a ventilation gas flow path from the gas inlet port to and through the gas outlet port, wherein the ventilation gas flow path is at least partially offset from the aerosol flow path and at least partially encircles the aerosol flow path. Systems and methods for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation incorporate the adaptor.

主权项

1. A ventilation circuit adaptor for providing ventilation gas and aerosol, the adaptor having an aerosol flowpath and a ventilation gas flowpath, the adaptor comprising:
(a) an aerosol flow chamber having a wall, the aerosol flow chamber extending along a longitudinal axis from an aerosol flow chamber inlet port to a patient interface port; (b) an aerosol flow channel disposed within the aerosol flow chamber, the aerosol flow channel having a longitudinal axis coaxial with the longitudinal axis of the aerosol flow chamber, the aerosol flow channel having a wall and extending from an aerosol flow channel inlet port to an aerosol flow channel outlet port, wherein the aerosol flow channel outlet port is in fluid communication with the patient interface port, wherein the aerosol flow channel inlet port is sealingly connected to the aerosol flow chamber, wherein an annular zone is provided and bounded by the wall of the aerosol flow channel and the wall of the aerosol flow chamber, the annular zone being in fluid communication with the patient interface port, such that the aerosol flowpath extends from the aerosol flow chamber inlet port, through the aerosol flow channel, and out the patient interface port; and (c) a ventilation gas flow chamber extending from a ventilation gas inlet port through the wall in the aerosol flow chamber, through and in fluid communication with the annular zone and the patient interface, and through the wall in the aerosol flow chamber and to a ventilation gas outlet port, such that the ventilation gas flowpath extends from the ventilation gas inlet port, and through the annular zone to the ventilation gas outlet port.