Methods and materials for therapeutic delivery

摘要

Methods for preparing a supramolecular therapeutic agent delivery assembly are provided. A hydrophilic precursor, a hydrophibic precursor, and an aromatic diamine precursor may be combined to form an amphiphilic block co-polymer. The block co-polymer may undergo a cross-linking polymerization process and a therapeutic agent may be incorporated into the resulting supramolecular assembly. The supramolecular assembly may comprise HT, PHT, HA, and/or PHA materials.

主权项

1. A method of preparing a supramolecular therapeutic agent delivery assembly comprising:
providing a first precursor comprising a cyclic carbonate-containing material, a second precursor comprising a polyethylene glycol with a carbonate or a diamine group, and a third precursor comprising an aromatic diamine; performing a ring opening polymerization to form a block co-polymer; cross-linking the block co-polymer by performing a PHT or PHA polymerization process to form a supramolecular assembly; and incorporating a therapeutic agent into the supramolecular assembly.